My preference would be to force the users to upload and modify files in a document management system such as MS SharePoint. While one would still have to deal with other files stored on local PC's, a centralized repository for storage of the most important data would aid in the disaster recovery of those files. Additionally, WSS (Windows SharePoint Services) 3.0 is free, as Compared to MOSS 2007 (Microsoft Office SharePoint Server), and easily acessible for any size company, the main restriction is the total size of the database, unless of course you already have SQL server licenses. The rest of the desktop backup strategy should at least include OS and application imaging, to maintain the ability to quickly install machines with all of the necessary software. As far as backing up the individual files on users PC's, one could, with enough storage, implement roaming profiles, or centralized My Documents folders. Even so, I believe that the most important option (For ease of backup, management, and restore) would be to force the users to use a centralized document repository, preferrably a web enabled database application.